| Orangeburg to Orangevale (California) | 2,263.06 mi (3,642.04 km) |
| Orangeburg to Orchards (Washington) | 2,341.80 mi (3,768.76 km) |
| Orangeburg to Orcutt (California) | 2,248.18 mi (3,618.09 km) |
| Orangeburg to Oregon (Ohio) | 580.93 mi (934.91 km) |
| Orangeburg to Oregon (Wisconsin) | 798.29 mi (1,284.73 km) |
| Orangeburg to Oregon City (Oregon) | 2,342.30 mi (3,769.56 km) |
| Orangeburg to Orem (Utah) | 1,757.49 mi (2,828.40 km) |
| Orangeburg to Orinda (California) | 2,319.16 mi (3,732.33 km) |
| Orangeburg to Orland Park (Illinois) | 678.54 mi (1,092.01 km) |
| Orangeburg to Orlando (Florida) | 347.65 mi (559.49 km) |
| Orangeburg to Ormond Beach (Florida) | 290.13 mi (466.91 km) |
| Orangeburg to Oro Valley (Arizona) | 1,741.06 mi (2,801.97 km) |
| Orangeburg to Oroville (California) | 2,278.45 mi (3,666.80 km) |
| Orangeburg to Oshkosh (Wisconsin) | 836.47 mi (1,346.17 km) |
| Orangeburg to Oskaloosa (Iowa) | 840.10 mi (1,352.01 km) |
