| Orangeburg to Olympia (Washington) | 2,370.55 mi (3,815.04 km) |
| Orangeburg to Olympia Heights (Florida) | 537.71 mi (865.36 km) |
| Orangeburg to Omaha (Nebraska) | 989.42 mi (1,592.32 km) |
| Orangeburg to On Top of the World Designated Place (Florida) | 314.47 mi (506.09 km) |
| Orangeburg to Onalaska (Wisconsin) | 907.77 mi (1,460.91 km) |
| Orangeburg to Oneida (New York) | 719.47 mi (1,157.87 km) |
| Orangeburg to Oneonta (New York) | 694.73 mi (1,118.06 km) |
| Orangeburg to Ontario (California) | 2,099.09 mi (3,378.15 km) |
| Orangeburg to Ontario (Oregon) | 2,057.44 mi (3,311.13 km) |
| Orangeburg to Opa-locka (Florida) | 525.91 mi (846.38 km) |
| Orangeburg to Opelika (Alabama) | 267.32 mi (430.21 km) |
| Orangeburg to Opelousas (Louisiana) | 687.86 mi (1,107.00 km) |
| Orangeburg to Orange (California) | 2,114.00 mi (3,402.16 km) |
| Orangeburg to Orange (Texas) | 791.42 mi (1,273.67 km) |
| Orangeburg to Orange City (Florida) | 315.91 mi (508.40 km) |
