| Orangeburg to Mattoon (Illinois) | 586.38 mi (943.69 km) |
| Orangeburg to Mauldin (South Carolina) | 121.16 mi (194.99 km) |
| Orangeburg to Maumee (Ohio) | 578.61 mi (931.19 km) |
| Orangeburg to Maumelle (Arkansas) | 665.54 mi (1,071.09 km) |
| Orangeburg to Mayagüez (Puerto Rico) | 1,355.35 mi (2,181.22 km) |
| Orangeburg to Mayfield Heights (Ohio) | 555.37 mi (893.79 km) |
| Orangeburg to Mays Chapel (Maryland) | 472.50 mi (760.42 km) |
| Orangeburg to Maywood (California) | 2,132.50 mi (3,431.92 km) |
| Orangeburg to Maywood (Illinois) | 693.22 mi (1,115.62 km) |
| Orangeburg to McAlester (Oklahoma) | 856.66 mi (1,378.66 km) |
| Orangeburg to McAllen (Texas) | 1,154.00 mi (1,857.18 km) |
| Orangeburg to McCalla (Alabama) | 355.70 mi (572.45 km) |
| Orangeburg to McComb (Mississippi) | 581.37 mi (935.63 km) |
| Orangeburg to McDonough (Georgia) | 189.28 mi (304.61 km) |
| Orangeburg to McFarland (California) | 2,174.24 mi (3,499.10 km) |
