| Orangeburg to Lovington (New Mexico) | 1,296.60 mi (2,086.67 km) |
| Orangeburg to Lowell (Indiana) | 647.41 mi (1,041.90 km) |
| Orangeburg to Lowell (Massachusetts) | 816.76 mi (1,314.44 km) |
| Orangeburg to Lower Burrell (Pennsylvania) | 493.90 mi (794.85 km) |
| Orangeburg to Lowes Island (Virginia) | 430.73 mi (693.19 km) |
| Orangeburg to Lubbock (Texas) | 1,208.64 mi (1,945.12 km) |
| Orangeburg to Lufkin (Texas) | 821.66 mi (1,322.33 km) |
| Orangeburg to Luling (Louisiana) | 610.01 mi (981.71 km) |
| Orangeburg to Lumberton (North Carolina) | 131.84 mi (212.17 km) |
| Orangeburg to Lumberton (Texas) | 813.34 mi (1,308.94 km) |
| Orangeburg to Lutz (Florida) | 381.54 mi (614.04 km) |
| Orangeburg to Lynbrook (New York) | 633.78 mi (1,019.97 km) |
| Orangeburg to Lynchburg (Virginia) | 285.98 mi (460.24 km) |
| Orangeburg to Lynden (Washington) | 2,372.10 mi (3,817.52 km) |
| Orangeburg to Lyndhurst (Ohio) | 555.49 mi (893.97 km) |
