| Orangeburg to Isabela (Puerto Rico) | 1,343.34 mi (2,161.89 km) |
| Orangeburg to Iselin (New Jersey) | 607.54 mi (977.75 km) |
| Orangeburg to Isla Vista (California) | 2,221.85 mi (3,575.73 km) |
| Orangeburg to Issaquah (Washington) | 2,336.43 mi (3,760.12 km) |
| Orangeburg to Ithaca (New York) | 662.33 mi (1,065.92 km) |
| Orangeburg to Ives Estates (Florida) | 521.86 mi (839.85 km) |
| Orangeburg to Jackson (Michigan) | 634.45 mi (1,021.05 km) |
| Orangeburg to Jackson (Mississippi) | 547.99 mi (881.90 km) |
| Orangeburg to Jackson (Missouri) | 562.40 mi (905.09 km) |
| Orangeburg to Jackson (Tennessee) | 477.11 mi (767.84 km) |
| Orangeburg to Jackson (Wyoming) | 1,746.27 mi (2,810.35 km) |
| Orangeburg to Jacksonville (Alabama) | 281.92 mi (453.71 km) |
| Orangeburg to Jacksonville (Arkansas) | 650.49 mi (1,046.87 km) |
| Orangeburg to Jacksonville (Florida) | 223.45 mi (359.61 km) |
| Orangeburg to Jacksonville (Illinois) | 674.16 mi (1,084.96 km) |
