| Orangeburg to Enterprise (Nevada) | 1,948.31 mi (3,135.51 km) |
| Orangeburg to Enumclaw (Washington) | 2,330.02 mi (3,749.81 km) |
| Orangeburg to Ephrata (Pennsylvania) | 529.60 mi (852.31 km) |
| Orangeburg to Erie (Colorado) | 1,407.10 mi (2,264.51 km) |
| Orangeburg to Erie (Pennsylvania) | 597.42 mi (961.45 km) |
| Orangeburg to Erlanger (Kentucky) | 433.84 mi (698.20 km) |
| Orangeburg to Escanaba (Michigan) | 908.47 mi (1,462.04 km) |
| Orangeburg to Escondido (California) | 2,079.84 mi (3,347.17 km) |
| Orangeburg to Española (New Mexico) | 1,437.16 mi (2,312.89 km) |
| Orangeburg to Essex (Maryland) | 470.58 mi (757.33 km) |
| Orangeburg to Essex Junction (Vermont) | 865.46 mi (1,392.83 km) |
| Orangeburg to Estelle (Louisiana) | 598.38 mi (963.01 km) |
| Orangeburg to Estero (Florida) | 491.30 mi (790.67 km) |
| Orangeburg to Euclid (Ohio) | 560.62 mi (902.22 km) |
| Orangeburg to Eufaula (Alabama) | 271.96 mi (437.68 km) |
