| Orangeburg to Elyria (Ohio) | 548.88 mi (883.34 km) |
| Orangeburg to Emeryville (California) | 2,325.64 mi (3,742.76 km) |
| Orangeburg to Emmaus (Pennsylvania) | 569.38 mi (916.32 km) |
| Orangeburg to Emporia (Kansas) | 920.49 mi (1,481.39 km) |
| Orangeburg to Encinitas (California) | 2,091.68 mi (3,366.24 km) |
| Orangeburg to Endicott (New York) | 649.54 mi (1,045.33 km) |
| Orangeburg to Endwell (New York) | 651.73 mi (1,048.86 km) |
| Orangeburg to Englewood (Colorado) | 1,399.72 mi (2,252.63 km) |
| Orangeburg to Englewood (Florida) | 459.19 mi (738.99 km) |
| Orangeburg to Englewood (New Jersey) | 636.15 mi (1,023.79 km) |
| Orangeburg to Englewood (Ohio) | 479.62 mi (771.87 km) |
| Orangeburg to Enid (Oklahoma) | 982.35 mi (1,580.93 km) |
| Orangeburg to Ennis (Texas) | 917.28 mi (1,476.22 km) |
| Orangeburg to Ensley (Florida) | 427.53 mi (688.05 km) |
| Orangeburg to Enterprise (Alabama) | 326.65 mi (525.69 km) |
