| Orangeburg to Effingham (Illinois) | 577.71 mi (929.74 km) |
| Orangeburg to Eggertsville (New York) | 663.99 mi (1,068.59 km) |
| Orangeburg to Egypt Lake-Leto (Florida) | 390.59 mi (628.60 km) |
| Orangeburg to El Cajon (California) | 2,077.90 mi (3,344.06 km) |
| Orangeburg to El Campo (Texas) | 955.06 mi (1,537.03 km) |
| Orangeburg to El Centro (California) | 1,998.29 mi (3,215.94 km) |
| Orangeburg to El Cerrito (California) | 2,325.62 mi (3,742.73 km) |
| Orangeburg to El Dorado (Arkansas) | 680.72 mi (1,095.51 km) |
| Orangeburg to El Dorado (Kansas) | 944.94 mi (1,520.74 km) |
| Orangeburg to El Dorado Hills (California) | 2,253.86 mi (3,627.23 km) |
| Orangeburg to El Mirage (Arizona) | 1,804.65 mi (2,904.30 km) |
| Orangeburg to El Monte (California) | 2,122.56 mi (3,415.92 km) |
| Orangeburg to El Paso (Texas) | 1,487.39 mi (2,393.72 km) |
| Orangeburg to El Paso de Robles (California) | 2,253.30 mi (3,626.34 km) |
| Orangeburg to El Reno (Oklahoma) | 982.40 mi (1,581.03 km) |
