| Opfikon to Southern Pines (North Carolina) | 4,396.98 mi (7,076.26 km) |
| Opfikon to Southfield (Michigan) | 4,229.95 mi (6,807.45 km) |
| Opfikon to Southgate (Michigan) | 4,239.76 mi (6,823.23 km) |
| Opfikon to Southlake (Texas) | 5,230.88 mi (8,418.28 km) |
| Opfikon to Spanaway (Washington) | 5,269.35 mi (8,480.20 km) |
| Opfikon to Spanish Fork (Utah) | 5,363.83 mi (8,632.25 km) |
| Opfikon to Spanish Lake (Missouri) | 4,671.27 mi (7,517.68 km) |
| Opfikon to Spanish Springs (Nevada) | 5,631.53 mi (9,063.07 km) |
| Opfikon to Sparks (Nevada) | 5,637.71 mi (9,073.02 km) |
| Opfikon to Spartanburg (South Carolina) | 4,515.19 mi (7,266.50 km) |
| Opfikon to Spearfish (South Dakota) | 4,877.06 mi (7,848.87 km) |
| Opfikon to Speedway (Indiana) | 4,468.63 mi (7,191.57 km) |
| Opfikon to Spencer (Iowa) | 4,646.97 mi (7,478.58 km) |
| Opfikon to Spokane (Washington) | 5,108.59 mi (8,221.48 km) |
| Opfikon to Spokane Valley (Washington) | 5,103.58 mi (8,213.41 km) |
