| Opelousas to University Place (Washington) | 1,983.39 mi (3,191.95 km) |
| Opelousas to Upland (California) | 1,509.90 mi (2,429.96 km) |
| Opelousas to Upper Arlington (Ohio) | 829.29 mi (1,334.61 km) |
| Opelousas to Upper Grand Lagoon (Florida) | 378.83 mi (609.67 km) |
| Opelousas to Upper Montclair (New Jersey) | 1,226.99 mi (1,974.64 km) |
| Opelousas to Urbana (Illinois) | 697.35 mi (1,122.28 km) |
| Opelousas to Urbana (Maryland) | 1,030.72 mi (1,658.79 km) |
| Opelousas to Urbana (Ohio) | 810.82 mi (1,304.89 km) |
| Opelousas to Urbandale (Iowa) | 773.68 mi (1,245.12 km) |
| Opelousas to Utica (New York) | 1,269.71 mi (2,043.39 km) |
| Opelousas to Uvalde (Texas) | 469.83 mi (756.12 km) |
| Opelousas to Vacaville (California) | 1,777.81 mi (2,861.10 km) |
| Opelousas to Vadnais Heights (Minnesota) | 1,005.49 mi (1,618.18 km) |
| Opelousas to Vail (Arizona) | 1,102.60 mi (1,774.46 km) |
| Opelousas to Valdosta (Georgia) | 523.39 mi (842.31 km) |
