| Opelousas to Superior (Colorado) | 981.58 mi (1,579.69 km) |
| Opelousas to Superior (Wisconsin) | 1,117.16 mi (1,797.90 km) |
| Opelousas to Surprise (Arizona) | 1,209.91 mi (1,947.17 km) |
| Opelousas to Susanville (California) | 1,735.07 mi (2,792.33 km) |
| Opelousas to Sussex (Wisconsin) | 896.70 mi (1,443.11 km) |
| Opelousas to Suwanee (Georgia) | 527.39 mi (848.76 km) |
| Opelousas to Swansea (Illinois) | 567.14 mi (912.73 km) |
| Opelousas to Sweetwater (Florida) | 784.31 mi (1,262.22 km) |
| Opelousas to Sweetwater (Texas) | 508.50 mi (818.35 km) |
| Opelousas to Sycamore (Illinois) | 814.66 mi (1,311.06 km) |
| Opelousas to Sylacauga (Alabama) | 387.60 mi (623.79 km) |
| Opelousas to Sylvania (Ohio) | 902.02 mi (1,451.66 km) |
| Opelousas to Syosset (New York) | 1,257.94 mi (2,024.45 km) |
| Opelousas to Syracuse (New York) | 1,231.06 mi (1,981.21 km) |
| Opelousas to Syracuse (Utah) | 1,331.69 mi (2,143.16 km) |
