| Opelousas to Storm Lake (Iowa) | 854.73 mi (1,375.56 km) |
| Opelousas to Storrs (Connecticut) | 1,347.83 mi (2,169.12 km) |
| Opelousas to Stoughton (Wisconsin) | 871.01 mi (1,401.76 km) |
| Opelousas to Stow (Ohio) | 945.60 mi (1,521.80 km) |
| Opelousas to Streamwood (Illinois) | 823.25 mi (1,324.89 km) |
| Opelousas to Streator (Illinois) | 754.50 mi (1,214.24 km) |
| Opelousas to Streetsboro (Ohio) | 951.93 mi (1,531.99 km) |
| Opelousas to Strongsville (Ohio) | 938.99 mi (1,511.16 km) |
| Opelousas to Stuart (Florida) | 751.85 mi (1,209.99 km) |
| Opelousas to Stuarts Draft (Virginia) | 905.70 mi (1,457.58 km) |
| Opelousas to Sturgis (Michigan) | 862.38 mi (1,387.87 km) |
| Opelousas to Suamico (Wisconsin) | 999.04 mi (1,607.79 km) |
| Opelousas to Sudley (Virginia) | 1,004.48 mi (1,616.56 km) |
| Opelousas to Suffern (New York) | 1,239.01 mi (1,994.00 km) |
| Opelousas to Suffolk (Virginia) | 983.89 mi (1,583.41 km) |
