| Opelousas to St. Simons (Georgia) | 635.79 mi (1,023.21 km) |
| Opelousas to Stafford (Texas) | 217.33 mi (349.76 km) |
| Opelousas to Stallings (North Carolina) | 734.31 mi (1,181.75 km) |
| Opelousas to Stamford (Connecticut) | 1,265.00 mi (2,035.83 km) |
| Opelousas to Stanford (California) | 1,780.10 mi (2,864.79 km) |
| Opelousas to Stanton (California) | 1,528.27 mi (2,459.52 km) |
| Opelousas to Star (Idaho) | 1,614.30 mi (2,597.96 km) |
| Opelousas to Starkville (Mississippi) | 278.27 mi (447.83 km) |
| Opelousas to State College (Pennsylvania) | 1,065.53 mi (1,714.80 km) |
| Opelousas to Staten Island (New York) | 1,220.48 mi (1,964.17 km) |
| Opelousas to Statesboro (Georgia) | 621.22 mi (999.76 km) |
| Opelousas to Statesville (North Carolina) | 742.60 mi (1,195.10 km) |
| Opelousas to Staunton (Virginia) | 909.54 mi (1,463.76 km) |
| Opelousas to Steamboat Springs (Colorado) | 1,074.65 mi (1,729.48 km) |
| Opelousas to Steiner Ranch (Texas) | 346.48 mi (557.61 km) |
