| Opelousas to Southern Pines (North Carolina) | 802.54 mi (1,291.57 km) |
| Opelousas to Southfield (Michigan) | 958.87 mi (1,543.15 km) |
| Opelousas to Southgate (Michigan) | 944.82 mi (1,520.54 km) |
| Opelousas to Southlake (Texas) | 341.81 mi (550.09 km) |
| Opelousas to Spanaway (Washington) | 1,974.78 mi (3,178.11 km) |
| Opelousas to Spanish Fork (Utah) | 1,281.94 mi (2,063.09 km) |
| Opelousas to Spanish Lake (Missouri) | 580.74 mi (934.61 km) |
| Opelousas to Spanish Springs (Nevada) | 1,673.95 mi (2,693.96 km) |
| Opelousas to Sparks (Nevada) | 1,675.03 mi (2,695.70 km) |
| Opelousas to Spartanburg (South Carolina) | 664.09 mi (1,068.75 km) |
| Opelousas to Spearfish (South Dakota) | 1,156.93 mi (1,861.90 km) |
| Opelousas to Speedway (Indiana) | 719.77 mi (1,158.35 km) |
| Opelousas to Spencer (Iowa) | 888.28 mi (1,429.55 km) |
| Opelousas to Spokane (Washington) | 1,788.11 mi (2,877.68 km) |
| Opelousas to Spokane Valley (Washington) | 1,780.15 mi (2,864.88 km) |
