| Opelousas to Smyrna (Delaware) | 1,109.99 mi (1,786.35 km) |
| Opelousas to Smyrna (Georgia) | 498.63 mi (802.47 km) |
| Opelousas to Smyrna (Tennessee) | 494.26 mi (795.44 km) |
| Opelousas to Snellville (Georgia) | 525.19 mi (845.20 km) |
| Opelousas to Snoqualmie (Washington) | 1,962.86 mi (3,158.91 km) |
| Opelousas to Snyder (Texas) | 540.88 mi (870.46 km) |
| Opelousas to Socastee (South Carolina) | 795.04 mi (1,279.49 km) |
| Opelousas to Socorro (Texas) | 841.91 mi (1,354.93 km) |
| Opelousas to Soddy-Daisy (Tennessee) | 516.96 mi (831.96 km) |
| Opelousas to Solana Beach (California) | 1,485.26 mi (2,390.29 km) |
| Opelousas to Soledad (California) | 1,727.86 mi (2,780.73 km) |
| Opelousas to Solon (Ohio) | 956.19 mi (1,538.84 km) |
| Opelousas to Somers Point (New Jersey) | 1,158.38 mi (1,864.23 km) |
| Opelousas to Somerset (Kentucky) | 623.49 mi (1,003.41 km) |
| Opelousas to Somerset (New Jersey) | 1,201.85 mi (1,934.19 km) |
