| Opelousas to Silver Firs (Washington) | 1,985.90 mi (3,195.99 km) |
| Opelousas to Silver Spring (Maryland) | 1,034.05 mi (1,664.14 km) |
| Opelousas to Silver Springs Shores (Florida) | 611.07 mi (983.43 km) |
| Opelousas to Silverdale (Washington) | 2,002.31 mi (3,222.41 km) |
| Opelousas to Silverton (Oregon) | 1,935.11 mi (3,114.26 km) |
| Opelousas to Simi Valley (California) | 1,572.47 mi (2,530.64 km) |
| Opelousas to Simpsonville (South Carolina) | 640.81 mi (1,031.28 km) |
| Opelousas to Sioux City (Iowa) | 860.68 mi (1,385.13 km) |
| Opelousas to Sioux Falls (South Dakota) | 934.64 mi (1,504.17 km) |
| Opelousas to Skokie (Illinois) | 830.95 mi (1,337.29 km) |
| Opelousas to Sleepy Hollow (New York) | 1,250.46 mi (2,012.42 km) |
| Opelousas to Slidell (Louisiana) | 137.95 mi (222.01 km) |
| Opelousas to Smithfield (North Carolina) | 865.95 mi (1,393.62 km) |
| Opelousas to Smithfield (Utah) | 1,344.88 mi (2,164.37 km) |
| Opelousas to Smithville (Missouri) | 628.61 mi (1,011.64 km) |
