| Opelousas to Seymour (Tennessee) | 606.11 mi (975.44 km) |
| Opelousas to Shady Hills (Florida) | 591.79 mi (952.39 km) |
| Opelousas to Shafter (California) | 1,602.89 mi (2,579.61 km) |
| Opelousas to Shaker Heights (Ohio) | 956.99 mi (1,540.13 km) |
| Opelousas to Shakopee (Minnesota) | 987.44 mi (1,589.14 km) |
| Opelousas to Sharon (Pennsylvania) | 981.95 mi (1,580.29 km) |
| Opelousas to Sharonville (Ohio) | 744.46 mi (1,198.10 km) |
| Opelousas to Shasta Lake (California) | 1,829.30 mi (2,943.98 km) |
| Opelousas to Shawnee (Kansas) | 606.61 mi (976.25 km) |
| Opelousas to Shawnee (Oklahoma) | 437.41 mi (703.94 km) |
| Opelousas to Sheboygan (Wisconsin) | 943.62 mi (1,518.61 km) |
| Opelousas to Shelby (North Carolina) | 693.66 mi (1,116.33 km) |
| Opelousas to Shelbyville (Indiana) | 716.93 mi (1,153.79 km) |
| Opelousas to Shelbyville (Kentucky) | 658.64 mi (1,059.98 km) |
| Opelousas to Shelbyville (Tennessee) | 473.61 mi (762.20 km) |
