| Opelousas to Security-Widefield (Colorado) | 914.19 mi (1,471.24 km) |
| Opelousas to Sedalia (Missouri) | 569.00 mi (915.72 km) |
| Opelousas to Sedro-Woolley (Washington) | 2,009.35 mi (3,233.74 km) |
| Opelousas to Seguin (Texas) | 357.84 mi (575.89 km) |
| Opelousas to Selden (New York) | 1,280.73 mi (2,061.13 km) |
| Opelousas to Selma (Alabama) | 324.87 mi (522.82 km) |
| Opelousas to Selma (California) | 1,633.32 mi (2,628.57 km) |
| Opelousas to Selma (Texas) | 378.21 mi (608.68 km) |
| Opelousas to Seminole (Florida) | 590.43 mi (950.21 km) |
| Opelousas to Seven Hills (Ohio) | 947.87 mi (1,525.45 km) |
| Opelousas to Seven Oaks (South Carolina) | 683.22 mi (1,099.53 km) |
| Opelousas to Severn (Maryland) | 1,053.74 mi (1,695.83 km) |
| Opelousas to Severna Park (Maryland) | 1,058.01 mi (1,702.71 km) |
| Opelousas to Sevierville (Tennessee) | 615.60 mi (990.72 km) |
| Opelousas to Seymour (Indiana) | 679.42 mi (1,093.42 km) |
