| Opelousas to Scottsboro (Alabama) | 451.85 mi (727.18 km) |
| Opelousas to Scottsdale (Arizona) | 1,176.36 mi (1,893.18 km) |
| Opelousas to Scranton (Pennsylvania) | 1,182.93 mi (1,903.74 km) |
| Opelousas to Seabrook (Maryland) | 1,041.23 mi (1,675.69 km) |
| Opelousas to Seabrook (Texas) | 187.78 mi (302.21 km) |
| Opelousas to Seaford (New York) | 1,253.54 mi (2,017.37 km) |
| Opelousas to Seagoville (Texas) | 301.02 mi (484.45 km) |
| Opelousas to Seal Beach (California) | 1,532.67 mi (2,466.60 km) |
| Opelousas to Searcy (Arkansas) | 326.50 mi (525.46 km) |
| Opelousas to Seaside (California) | 1,755.37 mi (2,824.99 km) |
| Opelousas to SeaTac (Washington) | 1,979.57 mi (3,185.81 km) |
| Opelousas to Seattle (Washington) | 1,985.90 mi (3,195.99 km) |
| Opelousas to Sebastian (Florida) | 724.73 mi (1,166.35 km) |
| Opelousas to Sebring (Florida) | 675.59 mi (1,087.25 km) |
| Opelousas to Secaucus (New Jersey) | 1,230.98 mi (1,981.06 km) |
