| Opelousas to Savannah (Georgia) | 651.67 mi (1,048.76 km) |
| Opelousas to Sayreville (New Jersey) | 1,208.53 mi (1,944.94 km) |
| Opelousas to Sayville (New York) | 1,275.02 mi (2,051.94 km) |
| Opelousas to Scaggsville (Maryland) | 1,045.18 mi (1,682.05 km) |
| Opelousas to Scarsdale (New York) | 1,251.21 mi (2,013.63 km) |
| Opelousas to Schaumburg (Illinois) | 825.29 mi (1,328.17 km) |
| Opelousas to Schenectady (New York) | 1,310.94 mi (2,109.75 km) |
| Opelousas to Schererville (Indiana) | 800.11 mi (1,287.66 km) |
| Opelousas to Schertz (Texas) | 375.00 mi (603.50 km) |
| Opelousas to Schiller Park (Illinois) | 823.81 mi (1,325.80 km) |
| Opelousas to Schofield Barracks (Hawaii) | 4,088.89 mi (6,580.43 km) |
| Opelousas to Scotchtown (New York) | 1,242.01 mi (1,998.83 km) |
| Opelousas to Scottdale (Georgia) | 509.85 mi (820.53 km) |
| Opelousas to Scotts Valley (California) | 1,768.81 mi (2,846.63 km) |
| Opelousas to Scottsbluff (Nebraska) | 1,013.45 mi (1,631.00 km) |
