| Opelousas to Santa Rosa (California) | 1,818.29 mi (2,926.26 km) |
| Opelousas to Santaquin (Utah) | 1,285.31 mi (2,068.50 km) |
| Opelousas to Santee (California) | 1,469.52 mi (2,364.96 km) |
| Opelousas to Sapulpa (Oklahoma) | 444.26 mi (714.96 km) |
| Opelousas to Saraland (Alabama) | 237.59 mi (382.37 km) |
| Opelousas to Sarasota (Florida) | 617.10 mi (993.13 km) |
| Opelousas to Sarasota Springs (Florida) | 621.79 mi (1,000.67 km) |
| Opelousas to Saratoga (California) | 1,771.18 mi (2,850.44 km) |
| Opelousas to Saratoga Springs (New York) | 1,327.56 mi (2,136.51 km) |
| Opelousas to Saratoga Springs (Utah) | 1,301.96 mi (2,095.30 km) |
| Opelousas to Sartell (Minnesota) | 1,049.23 mi (1,688.57 km) |
| Opelousas to Satellite Beach (Florida) | 709.75 mi (1,142.23 km) |
| Opelousas to Sauk Rapids (Minnesota) | 1,047.42 mi (1,685.66 km) |
| Opelousas to Sault Ste. Marie (Michigan) | 1,177.23 mi (1,894.57 km) |
| Opelousas to Savage (Minnesota) | 985.61 mi (1,586.19 km) |
