| Opelousas to Sanford (Maine) | 1,469.06 mi (2,364.22 km) |
| Opelousas to Sanford (North Carolina) | 821.67 mi (1,322.36 km) |
| Opelousas to Sanger (California) | 1,631.25 mi (2,625.25 km) |
| Opelousas to Santa Ana (California) | 1,521.76 mi (2,449.04 km) |
| Opelousas to Santa Barbara (California) | 1,628.21 mi (2,620.35 km) |
| Opelousas to Santa Clara (California) | 1,768.74 mi (2,846.52 km) |
| Opelousas to Santa Clara (Oregon) | 1,931.01 mi (3,107.66 km) |
| Opelousas to Santa Clarita (California) | 1,558.48 mi (2,508.14 km) |
| Opelousas to Santa Cruz (California) | 1,769.53 mi (2,847.78 km) |
| Opelousas to Santa Fe (New Mexico) | 878.31 mi (1,413.51 km) |
| Opelousas to Santa Fe (Texas) | 197.01 mi (317.06 km) |
| Opelousas to Santa Fe Springs (California) | 1,532.47 mi (2,466.27 km) |
| Opelousas to Santa Maria (California) | 1,670.56 mi (2,688.50 km) |
| Opelousas to Santa Monica (California) | 1,556.62 mi (2,505.13 km) |
| Opelousas to Santa Paula (California) | 1,590.74 mi (2,560.05 km) |
