| Opelousas to Salisbury (New York) | 1,252.93 mi (2,016.40 km) |
| Opelousas to Salisbury (North Carolina) | 758.39 mi (1,220.52 km) |
| Opelousas to Salmon Creek (Washington) | 1,947.46 mi (3,134.13 km) |
| Opelousas to Salt Lake City (Utah) | 1,315.69 mi (2,117.39 km) |
| Opelousas to Sammamish (Washington) | 1,973.45 mi (3,175.96 km) |
| Opelousas to San Angelo (Texas) | 499.63 mi (804.08 km) |
| Opelousas to San Anselmo (California) | 1,806.60 mi (2,907.44 km) |
| Opelousas to San Antonio (Texas) | 392.36 mi (631.45 km) |
| Opelousas to San Benito (Texas) | 454.48 mi (731.41 km) |
| Opelousas to San Bernardino (California) | 1,489.06 mi (2,396.41 km) |
| Opelousas to San Bruno (California) | 1,796.06 mi (2,890.49 km) |
| Opelousas to San Buenaventura (California) | 1,600.01 mi (2,574.97 km) |
| Opelousas to San Carlos (California) | 1,786.14 mi (2,874.51 km) |
| Opelousas to San Carlos Park (Florida) | 682.64 mi (1,098.60 km) |
| Opelousas to San Clemente (California) | 1,505.78 mi (2,423.32 km) |
