| Opelousas to Oswego (Illinois) | 798.56 mi (1,285.16 km) |
| Opelousas to Oswego (New York) | 1,235.70 mi (1,988.66 km) |
| Opelousas to Otsego (Minnesota) | 1,021.89 mi (1,644.57 km) |
| Opelousas to Ottawa (Illinois) | 769.98 mi (1,239.16 km) |
| Opelousas to Ottawa (Kansas) | 586.42 mi (943.75 km) |
| Opelousas to Ottumwa (Iowa) | 725.33 mi (1,167.31 km) |
| Opelousas to Overland (Missouri) | 572.89 mi (921.98 km) |
| Opelousas to Overland Park (Kansas) | 596.32 mi (959.68 km) |
| Opelousas to Overlea (Maryland) | 1,069.87 mi (1,721.79 km) |
| Opelousas to Oviedo (Florida) | 666.85 mi (1,073.19 km) |
| Opelousas to Owasso (Oklahoma) | 452.99 mi (729.02 km) |
| Opelousas to Owatonna (Minnesota) | 939.42 mi (1,511.85 km) |
| Opelousas to Owensboro (Kentucky) | 574.48 mi (924.54 km) |
| Opelousas to Owings Mills (Maryland) | 1,058.91 mi (1,704.15 km) |
| Opelousas to Owosso (Michigan) | 965.27 mi (1,553.45 km) |
