| Opelousas to Olympia (Washington) | 1,993.48 mi (3,208.19 km) |
| Opelousas to Olympia Heights (Florida) | 788.10 mi (1,268.32 km) |
| Opelousas to Omaha (Nebraska) | 774.23 mi (1,246.00 km) |
| Opelousas to On Top of the World Designated Place (Florida) | 595.12 mi (957.75 km) |
| Opelousas to Onalaska (Wisconsin) | 924.54 mi (1,487.90 km) |
| Opelousas to Oneida (New York) | 1,251.55 mi (2,014.17 km) |
| Opelousas to Oneonta (New York) | 1,249.74 mi (2,011.27 km) |
| Opelousas to Ontario (California) | 1,506.60 mi (2,424.64 km) |
| Opelousas to Ontario (Oregon) | 1,645.81 mi (2,648.67 km) |
| Opelousas to Opa-locka (Florida) | 787.20 mi (1,266.88 km) |
| Opelousas to Opelika (Alabama) | 421.18 mi (677.83 km) |
| Opelousas to Orange (California) | 1,518.42 mi (2,443.67 km) |
| Opelousas to Orange (Texas) | 103.93 mi (167.26 km) |
| Opelousas to Orange City (Florida) | 656.58 mi (1,056.66 km) |
| Opelousas to Orangeburg (South Carolina) | 687.86 mi (1,107.00 km) |
