| Opelousas to Mattoon (Illinois) | 653.20 mi (1,051.22 km) |
| Opelousas to Mauldin (South Carolina) | 639.94 mi (1,029.88 km) |
| Opelousas to Maumee (Ohio) | 895.29 mi (1,440.83 km) |
| Opelousas to Maumelle (Arkansas) | 299.54 mi (482.06 km) |
| Opelousas to Mayagüez (Puerto Rico) | 1,779.74 mi (2,864.21 km) |
| Opelousas to Mayfield Heights (Ohio) | 962.51 mi (1,549.01 km) |
| Opelousas to Mays Chapel (Maryland) | 1,066.13 mi (1,715.77 km) |
| Opelousas to Maywood (California) | 1,539.75 mi (2,478.00 km) |
| Opelousas to Maywood (Illinois) | 819.03 mi (1,318.10 km) |
| Opelousas to McAlester (Oklahoma) | 372.07 mi (598.79 km) |
| Opelousas to McAllen (Texas) | 478.10 mi (769.43 km) |
| Opelousas to McCalla (Alabama) | 352.90 mi (567.93 km) |
| Opelousas to McComb (Mississippi) | 107.62 mi (173.19 km) |
| Opelousas to McDonough (Georgia) | 506.36 mi (814.90 km) |
| Opelousas to McFarland (California) | 1,606.28 mi (2,585.06 km) |
