| Opelousas to Enterprise (Nevada) | 1,386.02 mi (2,230.59 km) |
| Opelousas to Enumclaw (Washington) | 1,959.33 mi (3,153.24 km) |
| Opelousas to Ephrata (Pennsylvania) | 1,114.21 mi (1,793.14 km) |
| Opelousas to Erie (Colorado) | 981.10 mi (1,578.92 km) |
| Opelousas to Erie (Pennsylvania) | 1,041.03 mi (1,675.37 km) |
| Opelousas to Erlanger (Kentucky) | 723.76 mi (1,164.79 km) |
| Opelousas to Escanaba (Michigan) | 1,085.61 mi (1,747.13 km) |
| Opelousas to Escondido (California) | 1,474.54 mi (2,373.04 km) |
| Opelousas to Española (New Mexico) | 891.15 mi (1,434.17 km) |
| Opelousas to Essex (Maryland) | 1,071.10 mi (1,723.76 km) |
| Opelousas to Essex Junction (Vermont) | 1,411.82 mi (2,272.11 km) |
| Opelousas to Estelle (Louisiana) | 127.23 mi (204.76 km) |
| Opelousas to Estero (Florida) | 685.49 mi (1,103.20 km) |
| Opelousas to Euclid (Ohio) | 964.08 mi (1,551.54 km) |
| Opelousas to Eufaula (Alabama) | 420.50 mi (676.72 km) |
