| Opelousas to Elyria (Ohio) | 933.12 mi (1,501.72 km) |
| Opelousas to Emeryville (California) | 1,790.37 mi (2,881.32 km) |
| Opelousas to Emmaus (Pennsylvania) | 1,157.67 mi (1,863.09 km) |
| Opelousas to Emporia (Kansas) | 592.36 mi (953.32 km) |
| Opelousas to Encinitas (California) | 1,485.45 mi (2,390.61 km) |
| Opelousas to Endicott (New York) | 1,194.05 mi (1,921.63 km) |
| Opelousas to Endwell (New York) | 1,196.61 mi (1,925.76 km) |
| Opelousas to Englewood (Colorado) | 962.62 mi (1,549.19 km) |
| Opelousas to Englewood (Florida) | 638.14 mi (1,026.99 km) |
| Opelousas to Englewood (New Jersey) | 1,238.94 mi (1,993.89 km) |
| Opelousas to Englewood (Ohio) | 779.69 mi (1,254.78 km) |
| Opelousas to Enid (Oklahoma) | 525.52 mi (845.75 km) |
| Opelousas to Ennis (Texas) | 295.82 mi (476.08 km) |
| Opelousas to Ensley (Florida) | 286.15 mi (460.52 km) |
| Opelousas to Enterprise (Alabama) | 373.65 mi (601.33 km) |
