| Opelousas to Effingham (Illinois) | 626.58 mi (1,008.39 km) |
| Opelousas to Eggertsville (New York) | 1,128.07 mi (1,815.46 km) |
| Opelousas to Egypt Lake-Leto (Florida) | 602.32 mi (969.35 km) |
| Opelousas to El Cajon (California) | 1,468.12 mi (2,362.71 km) |
| Opelousas to El Campo (Texas) | 267.25 mi (430.10 km) |
| Opelousas to El Centro (California) | 1,386.76 mi (2,231.77 km) |
| Opelousas to El Cerrito (California) | 1,791.60 mi (2,883.29 km) |
| Opelousas to El Dorado (Arkansas) | 189.19 mi (304.48 km) |
| Opelousas to El Dorado (Kansas) | 573.15 mi (922.40 km) |
| Opelousas to El Dorado Hills (California) | 1,732.38 mi (2,788.00 km) |
| Opelousas to El Mirage (Arizona) | 1,202.27 mi (1,934.86 km) |
| Opelousas to El Monte (California) | 1,530.87 mi (2,463.70 km) |
| Opelousas to El Paso (Texas) | 852.39 mi (1,371.78 km) |
| Opelousas to El Paso de Robles (California) | 1,685.25 mi (2,712.15 km) |
| Opelousas to El Reno (Oklahoma) | 485.98 mi (782.10 km) |
