| Opelousas to Eatontown (New Jersey) | 1,215.15 mi (1,955.60 km) |
| Opelousas to Eau Claire (Wisconsin) | 988.17 mi (1,590.30 km) |
| Opelousas to Echelon (New Jersey) | 1,156.88 mi (1,861.82 km) |
| Opelousas to Eden (North Carolina) | 821.14 mi (1,321.50 km) |
| Opelousas to Eden Prairie (Minnesota) | 992.49 mi (1,597.25 km) |
| Opelousas to Edgewater (Florida) | 676.77 mi (1,089.15 km) |
| Opelousas to Edgewater (New Jersey) | 1,236.61 mi (1,990.13 km) |
| Opelousas to Edgewood (Maryland) | 1,081.99 mi (1,741.30 km) |
| Opelousas to Edgewood (Washington) | 1,972.65 mi (3,174.68 km) |
| Opelousas to Edina (Minnesota) | 995.03 mi (1,601.35 km) |
| Opelousas to Edinburg (Texas) | 469.79 mi (756.05 km) |
| Opelousas to Edmond (Oklahoma) | 470.61 mi (757.38 km) |
| Opelousas to Edmonds (Washington) | 1,992.81 mi (3,207.12 km) |
| Opelousas to Edwards (Colorado) | 1,032.47 mi (1,661.59 km) |
| Opelousas to Edwardsville (Illinois) | 583.41 mi (938.91 km) |
