| Opelousas to Des Plaines (Illinois) | 828.32 mi (1,333.05 km) |
| Opelousas to Desert Hot Springs (California) | 1,445.49 mi (2,326.29 km) |
| Opelousas to DeSoto (Texas) | 315.84 mi (508.29 km) |
| Opelousas to Destin (Florida) | 334.29 mi (537.99 km) |
| Opelousas to Destrehan (Louisiana) | 109.44 mi (176.13 km) |
| Opelousas to Detroit (Michigan) | 958.00 mi (1,541.76 km) |
| Opelousas to Diamond Bar (California) | 1,518.50 mi (2,443.79 km) |
| Opelousas to Diamond Springs (California) | 1,721.45 mi (2,770.41 km) |
| Opelousas to Dickinson (North Dakota) | 1,266.97 mi (2,038.98 km) |
| Opelousas to Dickinson (Texas) | 192.90 mi (310.44 km) |
| Opelousas to Dickson (Tennessee) | 469.52 mi (755.61 km) |
| Opelousas to Difficult Run (Virginia) | 1,015.37 mi (1,634.08 km) |
| Opelousas to Dinuba (California) | 1,621.22 mi (2,609.10 km) |
| Opelousas to Discovery Bay (California) | 1,753.47 mi (2,821.94 km) |
| Opelousas to Dix Hills (New York) | 1,265.10 mi (2,035.98 km) |
