| Opelousas to Delaware (Ohio) | 842.80 mi (1,356.36 km) |
| Opelousas to Delhi (California) | 1,704.38 mi (2,742.94 km) |
| Opelousas to Delray Beach (Florida) | 780.04 mi (1,255.35 km) |
| Opelousas to Deltona (Florida) | 661.41 mi (1,064.44 km) |
| Opelousas to Deming (New Mexico) | 931.16 mi (1,498.55 km) |
| Opelousas to Denison (Texas) | 345.55 mi (556.11 km) |
| Opelousas to Dent (Ohio) | 731.22 mi (1,176.78 km) |
| Opelousas to Denton (Texas) | 350.30 mi (563.76 km) |
| Opelousas to Dentsville (South Carolina) | 694.10 mi (1,117.04 km) |
| Opelousas to Denver (Colorado) | 962.43 mi (1,548.88 km) |
| Opelousas to Depew (New York) | 1,129.05 mi (1,817.02 km) |
| Opelousas to Derby (Connecticut) | 1,294.07 mi (2,082.60 km) |
| Opelousas to Derby (Kansas) | 568.78 mi (915.36 km) |
| Opelousas to Des Moines (Iowa) | 768.02 mi (1,236.01 km) |
| Opelousas to Des Moines (Washington) | 1,978.73 mi (3,184.45 km) |
