| Old Jamestown to Southern Pines (North Carolina) | 650.46 mi (1,046.81 km) |
| Old Jamestown to Southfield (Michigan) | 445.52 mi (716.99 km) |
| Old Jamestown to Southgate (Michigan) | 438.29 mi (705.36 km) |
| Old Jamestown to Southlake (Texas) | 559.11 mi (899.79 km) |
| Old Jamestown to Spanaway (Washington) | 1,707.84 mi (2,748.50 km) |
| Old Jamestown to Spanish Fork (Utah) | 1,139.61 mi (1,834.02 km) |
| Old Jamestown to Spanish Lake (Missouri) | 5.44 mi (8.76 km) |
| Old Jamestown to Spanish Springs (Nevada) | 1,566.26 mi (2,520.65 km) |
| Old Jamestown to Sparks (Nevada) | 1,569.48 mi (2,525.83 km) |
| Old Jamestown to Spartanburg (South Carolina) | 534.29 mi (859.85 km) |
| Old Jamestown to Spearfish (South Dakota) | 798.69 mi (1,285.36 km) |
| Old Jamestown to Speedway (Indiana) | 225.60 mi (363.07 km) |
| Old Jamestown to Spencer (Iowa) | 391.06 mi (629.35 km) |
| Old Jamestown to Spokane (Washington) | 1,486.08 mi (2,391.62 km) |
| Old Jamestown to Spokane Valley (Washington) | 1,477.06 mi (2,377.10 km) |
