| Old Jamestown to Enterprise (Nevada) | 1,378.18 mi (2,217.96 km) |
| Old Jamestown to Enumclaw (Washington) | 1,688.67 mi (2,717.64 km) |
| Old Jamestown to Ephrata (Pennsylvania) | 756.68 mi (1,217.76 km) |
| Old Jamestown to Erie (Colorado) | 790.78 mi (1,272.64 km) |
| Old Jamestown to Erie (Pennsylvania) | 582.00 mi (936.63 km) |
| Old Jamestown to Erlanger (Kentucky) | 306.48 mi (493.23 km) |
| Old Jamestown to Escanaba (Michigan) | 504.36 mi (811.68 km) |
| Old Jamestown to Escondido (California) | 1,542.44 mi (2,482.32 km) |
| Old Jamestown to Española (New Mexico) | 886.75 mi (1,427.09 km) |
| Old Jamestown to Essex (Maryland) | 742.36 mi (1,194.71 km) |
| Old Jamestown to Essex Junction (Vermont) | 966.00 mi (1,554.63 km) |
| Old Jamestown to Estelle (Louisiana) | 621.56 mi (1,000.30 km) |
| Old Jamestown to Estero (Florida) | 988.52 mi (1,590.87 km) |
| Old Jamestown to Euclid (Ohio) | 499.73 mi (804.24 km) |
| Old Jamestown to Eufaula (Alabama) | 559.11 mi (899.80 km) |
