| Oklahoma City to Southern Pines (North Carolina) | 1,019.56 mi (1,640.83 km) |
| Oklahoma City to Southfield (Michigan) | 904.07 mi (1,454.96 km) |
| Oklahoma City to Southgate (Michigan) | 898.01 mi (1,445.21 km) |
| Oklahoma City to Southlake (Texas) | 174.87 mi (281.43 km) |
| Oklahoma City to Spanaway (Washington) | 1,512.56 mi (2,434.22 km) |
| Oklahoma City to Spanish Fork (Utah) | 834.18 mi (1,342.48 km) |
| Oklahoma City to Spanish Lake (Missouri) | 463.05 mi (745.21 km) |
| Oklahoma City to Spanish Springs (Nevada) | 1,244.02 mi (2,002.06 km) |
| Oklahoma City to Sparks (Nevada) | 1,245.86 mi (2,005.02 km) |
| Oklahoma City to Spartanburg (South Carolina) | 879.88 mi (1,416.03 km) |
| Oklahoma City to Spearfish (South Dakota) | 706.58 mi (1,137.12 km) |
| Oklahoma City to Speedway (Indiana) | 684.39 mi (1,101.41 km) |
| Oklahoma City to Spencer (Iowa) | 545.31 mi (877.59 km) |
| Oklahoma City to Spokane (Washington) | 1,323.85 mi (2,130.53 km) |
| Oklahoma City to Spokane Valley (Washington) | 1,315.89 mi (2,117.72 km) |
