| North Fort Myers to Olympia Heights (Florida) | 116.33 mi (187.22 km) |
| North Fort Myers to Omaha (Nebraska) | 1,289.04 mi (2,074.51 km) |
| North Fort Myers to On Top of the World Designated Place (Florida) | 166.70 mi (268.27 km) |
| North Fort Myers to Onalaska (Wisconsin) | 1,295.92 mi (2,085.58 km) |
| North Fort Myers to Oneida (New York) | 1,182.09 mi (1,902.40 km) |
| North Fort Myers to Oneonta (New York) | 1,152.30 mi (1,854.45 km) |
| North Fort Myers to Ontario (California) | 2,178.71 mi (3,506.29 km) |
| North Fort Myers to Ontario (Oregon) | 2,286.49 mi (3,679.74 km) |
| North Fort Myers to Opa-locka (Florida) | 113.95 mi (183.39 km) |
| North Fort Myers to Opelika (Alabama) | 461.55 mi (742.79 km) |
| North Fort Myers to Opelousas (Louisiana) | 673.52 mi (1,083.93 km) |
| North Fort Myers to Orange (California) | 2,190.08 mi (3,524.59 km) |
| North Fort Myers to Orange (Texas) | 760.49 mi (1,223.90 km) |
| North Fort Myers to Orange City (Florida) | 156.51 mi (251.89 km) |
| North Fort Myers to Orangeburg (South Carolina) | 471.31 mi (758.50 km) |
