| North Charleston to Southern Pines (North Carolina) | 162.51 mi (261.54 km) |
| North Charleston to Southfield (Michigan) | 683.65 mi (1,100.24 km) |
| North Charleston to Southgate (Michigan) | 664.82 mi (1,069.93 km) |
| North Charleston to Southlake (Texas) | 989.31 mi (1,592.14 km) |
| North Charleston to Spanaway (Washington) | 2,410.11 mi (3,878.69 km) |
| North Charleston to Spanish Fork (Utah) | 1,811.78 mi (2,915.77 km) |
| North Charleston to Spanish Lake (Missouri) | 697.39 mi (1,122.34 km) |
| North Charleston to Spanish Springs (Nevada) | 2,235.45 mi (3,597.60 km) |
| North Charleston to Sparks (Nevada) | 2,238.00 mi (3,601.71 km) |
| North Charleston to Spartanburg (South Carolina) | 176.35 mi (283.81 km) |
| North Charleston to Spearfish (South Dakota) | 1,501.40 mi (2,416.28 km) |
| North Charleston to Speedway (Indiana) | 586.63 mi (944.08 km) |
| North Charleston to Spencer (Iowa) | 1,080.62 mi (1,739.10 km) |
| North Charleston to Spokane (Washington) | 2,188.84 mi (3,522.60 km) |
| North Charleston to Spokane Valley (Washington) | 2,179.81 mi (3,508.07 km) |
