| North Charleston to Scottsboro (Alabama) | 363.57 mi (585.11 km) |
| North Charleston to Scottsdale (Arizona) | 1,829.58 mi (2,944.42 km) |
| North Charleston to Scranton (Pennsylvania) | 635.08 mi (1,022.06 km) |
| North Charleston to Seabrook (Maryland) | 456.62 mi (734.85 km) |
| North Charleston to Seabrook (Texas) | 911.83 mi (1,467.45 km) |
| North Charleston to Seaford (New York) | 647.71 mi (1,042.39 km) |
| North Charleston to Seagoville (Texas) | 956.14 mi (1,538.76 km) |
| North Charleston to Seal Beach (California) | 2,181.88 mi (3,511.39 km) |
| North Charleston to Searcy (Arkansas) | 686.24 mi (1,104.40 km) |
| North Charleston to Seaside (California) | 2,364.93 mi (3,805.98 km) |
| North Charleston to SeaTac (Washington) | 2,408.00 mi (3,875.30 km) |
| North Charleston to Seattle (Washington) | 2,411.15 mi (3,880.36 km) |
| North Charleston to Sebastian (Florida) | 354.91 mi (571.17 km) |
| North Charleston to Sebring (Florida) | 384.10 mi (618.15 km) |
| North Charleston to Secaucus (New Jersey) | 637.02 mi (1,025.19 km) |
