| North Charleston to Olympia Heights (Florida) | 496.54 mi (799.10 km) |
| North Charleston to Omaha (Nebraska) | 1,050.54 mi (1,690.67 km) |
| North Charleston to On Top of the World Designated Place (Florida) | 293.52 mi (472.37 km) |
| North Charleston to Onalaska (Wisconsin) | 967.28 mi (1,556.68 km) |
| North Charleston to Oneida (New York) | 742.29 mi (1,194.61 km) |
| North Charleston to Oneonta (New York) | 713.91 mi (1,148.92 km) |
| North Charleston to Ontario (California) | 2,152.48 mi (3,464.08 km) |
| North Charleston to Ontario (Oregon) | 2,117.84 mi (3,408.33 km) |
| North Charleston to Opa-locka (Florida) | 484.26 mi (779.34 km) |
| North Charleston to Opelika (Alabama) | 308.57 mi (496.60 km) |
| North Charleston to Opelousas (Louisiana) | 724.33 mi (1,165.69 km) |
| North Charleston to Orange (California) | 2,167.18 mi (3,487.74 km) |
| North Charleston to Orange (Texas) | 828.24 mi (1,332.92 km) |
| North Charleston to Orange City (Florida) | 283.73 mi (456.62 km) |
| North Charleston to Orangeburg (South Carolina) | 61.25 mi (98.58 km) |
