| North Charleston to Enterprise (Nevada) | 2,003.43 mi (3,224.20 km) |
| North Charleston to Enumclaw (Washington) | 2,391.07 mi (3,848.05 km) |
| North Charleston to Ephrata (Pennsylvania) | 546.90 mi (880.15 km) |
| North Charleston to Erie (Colorado) | 1,466.23 mi (2,359.67 km) |
| North Charleston to Erie (Pennsylvania) | 636.35 mi (1,024.11 km) |
| North Charleston to Erlanger (Kentucky) | 491.38 mi (790.80 km) |
| North Charleston to Escanaba (Michigan) | 962.29 mi (1,548.66 km) |
| North Charleston to Escondido (California) | 2,132.20 mi (3,431.45 km) |
| North Charleston to Española (New Mexico) | 1,491.94 mi (2,401.04 km) |
| North Charleston to Essex (Maryland) | 485.95 mi (782.05 km) |
| North Charleston to Essex Junction (Vermont) | 883.09 mi (1,421.20 km) |
| North Charleston to Estelle (Louisiana) | 628.02 mi (1,010.70 km) |
| North Charleston to Estero (Florida) | 459.43 mi (739.38 km) |
| North Charleston to Euclid (Ohio) | 605.20 mi (973.98 km) |
| North Charleston to Eufaula (Alabama) | 304.09 mi (489.38 km) |
