| Nogales to Southern Pines (North Carolina) | 1,832.63 mi (2,949.34 km) |
| Nogales to Southfield (Michigan) | 1,700.00 mi (2,735.88 km) |
| Nogales to Southgate (Michigan) | 1,697.05 mi (2,731.13 km) |
| Nogales to Southlake (Texas) | 813.09 mi (1,308.55 km) |
| Nogales to Spanaway (Washington) | 1,246.00 mi (2,005.24 km) |
| Nogales to Spanish Fork (Utah) | 605.70 mi (974.78 km) |
| Nogales to Spanish Lake (Missouri) | 1,275.54 mi (2,052.78 km) |
| Nogales to Spanish Springs (Nevada) | 754.06 mi (1,213.54 km) |
| Nogales to Sparks (Nevada) | 751.60 mi (1,209.58 km) |
| Nogales to Spartanburg (South Carolina) | 1,690.15 mi (2,720.04 km) |
| Nogales to Spearfish (South Dakota) | 985.58 mi (1,586.14 km) |
| Nogales to Speedway (Indiana) | 1,498.23 mi (2,411.17 km) |
| Nogales to Spencer (Iowa) | 1,186.19 mi (1,909.00 km) |
| Nogales to Spokane (Washington) | 1,177.54 mi (1,895.06 km) |
| Nogales to Spokane Valley (Washington) | 1,174.24 mi (1,889.76 km) |
