| Nicosia to Settimo Torinese | 1,507.95 mi (2,426.81 km) |
| Nicosia to Seveso | 1,457.21 mi (2,345.16 km) |
| Nicosia to Sezze | 1,180.20 mi (1,899.35 km) |
| Nicosia to Siano | 1,085.91 mi (1,747.60 km) |
| Nicosia to Siena | 1,301.09 mi (2,093.91 km) |
| Nicosia to Signa | 1,322.36 mi (2,128.13 km) |
| Nicosia to Silea | 1,317.64 mi (2,120.54 km) |
| Nicosia to Silvi Paese | 1,150.60 mi (1,851.71 km) |
| Nicosia to Sinalunga | 1,279.69 mi (2,059.47 km) |
| Nicosia to Siniscola | 1,339.11 mi (2,155.09 km) |
| Nicosia to Sinnai | 1,355.04 mi (2,180.73 km) |
| Nicosia to Siracusa | 1,015.84 mi (1,634.84 km) |
| Nicosia to Solaro | 1,458.92 mi (2,347.90 km) |
| Nicosia to Soliera | 1,353.40 mi (2,178.08 km) |
| Nicosia to Solofra | 1,078.61 mi (1,735.85 km) |
