| Nicholasville to Southern Pines (North Carolina) | 341.80 mi (550.07 km) |
| Nicholasville to Southfield (Michigan) | 324.26 mi (521.84 km) |
| Nicholasville to Southgate (Michigan) | 306.63 mi (493.48 km) |
| Nicholasville to Southlake (Texas) | 785.39 mi (1,263.96 km) |
| Nicholasville to Spanaway (Washington) | 2,008.31 mi (3,232.07 km) |
| Nicholasville to Spanish Fork (Utah) | 1,456.13 mi (2,343.42 km) |
| Nicholasville to Spanish Lake (Missouri) | 311.87 mi (501.91 km) |
| Nicholasville to Spanish Springs (Nevada) | 1,882.76 mi (3,030.01 km) |
| Nicholasville to Sparks (Nevada) | 1,886.00 mi (3,035.22 km) |
| Nicholasville to Spartanburg (South Carolina) | 251.00 mi (403.95 km) |
| Nicholasville to Spearfish (South Dakota) | 1,096.29 mi (1,764.31 km) |
| Nicholasville to Speedway (Indiana) | 159.61 mi (256.86 km) |
| Nicholasville to Spencer (Iowa) | 663.34 mi (1,067.55 km) |
| Nicholasville to Spokane (Washington) | 1,781.77 mi (2,867.48 km) |
| Nicholasville to Spokane Valley (Washington) | 1,772.63 mi (2,852.77 km) |
