| Nicholasville to Scottsboro (Alabama) | 239.04 mi (384.69 km) |
| Nicholasville to Scottsdale (Arizona) | 1,551.51 mi (2,496.91 km) |
| Nicholasville to Scranton (Pennsylvania) | 531.82 mi (855.88 km) |
| Nicholasville to Seabrook (Maryland) | 424.23 mi (682.73 km) |
| Nicholasville to Seabrook (Texas) | 830.26 mi (1,336.17 km) |
| Nicholasville to Seaford (New York) | 622.09 mi (1,001.16 km) |
| Nicholasville to Seagoville (Texas) | 765.64 mi (1,232.17 km) |
| Nicholasville to Seal Beach (California) | 1,888.38 mi (3,039.05 km) |
| Nicholasville to Searcy (Arkansas) | 437.71 mi (704.42 km) |
| Nicholasville to Seaside (California) | 2,036.89 mi (3,278.07 km) |
| Nicholasville to SeaTac (Washington) | 2,004.53 mi (3,225.98 km) |
| Nicholasville to Seattle (Washington) | 2,006.88 mi (3,229.76 km) |
| Nicholasville to Sebastian (Florida) | 737.36 mi (1,186.66 km) |
| Nicholasville to Sebring (Florida) | 741.81 mi (1,193.82 km) |
| Nicholasville to Secaucus (New Jersey) | 595.18 mi (957.84 km) |
