| Nicholasville to Santa Rosa (California) | 2,057.15 mi (3,310.67 km) |
| Nicholasville to Santaquin (Utah) | 1,464.74 mi (2,357.27 km) |
| Nicholasville to Santee (California) | 1,849.60 mi (2,976.64 km) |
| Nicholasville to Sapulpa (Oklahoma) | 649.52 mi (1,045.30 km) |
| Nicholasville to Saraland (Alabama) | 526.56 mi (847.42 km) |
| Nicholasville to Sarasota (Florida) | 738.46 mi (1,188.43 km) |
| Nicholasville to Sarasota Springs (Florida) | 741.15 mi (1,192.76 km) |
| Nicholasville to Saratoga (California) | 2,037.66 mi (3,279.30 km) |
| Nicholasville to Saratoga Springs (New York) | 669.60 mi (1,077.62 km) |
| Nicholasville to Saratoga Springs (Utah) | 1,469.92 mi (2,365.61 km) |
| Nicholasville to Sartell (Minnesota) | 728.82 mi (1,172.93 km) |
| Nicholasville to Satellite Beach (Florida) | 709.07 mi (1,141.13 km) |
| Nicholasville to Sauk Rapids (Minnesota) | 725.50 mi (1,167.59 km) |
| Nicholasville to Sault Ste. Marie (Michigan) | 593.67 mi (955.42 km) |
| Nicholasville to Savage (Minnesota) | 657.45 mi (1,058.07 km) |
