| Nicholasville to Olympia Heights (Florida) | 876.23 mi (1,410.16 km) |
| Nicholasville to Omaha (Nebraska) | 653.92 mi (1,052.39 km) |
| Nicholasville to On Top of the World Designated Place (Florida) | 620.96 mi (999.34 km) |
| Nicholasville to Onalaska (Wisconsin) | 540.02 mi (869.09 km) |
| Nicholasville to Oneida (New York) | 588.83 mi (947.63 km) |
| Nicholasville to Oneonta (New York) | 591.92 mi (952.60 km) |
| Nicholasville to Ontario (California) | 1,856.91 mi (2,988.40 km) |
| Nicholasville to Ontario (Oregon) | 1,731.26 mi (2,786.19 km) |
| Nicholasville to Opa-locka (Florida) | 865.94 mi (1,393.60 km) |
| Nicholasville to Opelika (Alabama) | 364.19 mi (586.11 km) |
| Nicholasville to Opelousas (Louisiana) | 665.34 mi (1,070.75 km) |
| Nicholasville to Orange (California) | 1,873.70 mi (3,015.42 km) |
| Nicholasville to Orange (Texas) | 751.12 mi (1,208.80 km) |
| Nicholasville to Orange City (Florida) | 646.90 mi (1,041.09 km) |
| Nicholasville to Orangeburg (South Carolina) | 367.93 mi (592.13 km) |
