| Nicholasville to Enterprise (Nevada) | 1,690.38 mi (2,720.40 km) |
| Nicholasville to Enumclaw (Washington) | 1,988.61 mi (3,200.36 km) |
| Nicholasville to Ephrata (Pennsylvania) | 476.82 mi (767.37 km) |
| Nicholasville to Erie (Colorado) | 1,107.34 mi (1,782.09 km) |
| Nicholasville to Erie (Pennsylvania) | 376.47 mi (605.87 km) |
| Nicholasville to Erlanger (Kentucky) | 77.41 mi (124.58 km) |
| Nicholasville to Escanaba (Michigan) | 558.12 mi (898.21 km) |
| Nicholasville to Escondido (California) | 1,847.82 mi (2,973.77 km) |
| Nicholasville to Española (New Mexico) | 1,191.76 mi (1,917.95 km) |
| Nicholasville to Essex (Maryland) | 449.13 mi (722.80 km) |
| Nicholasville to Essex Junction (Vermont) | 748.81 mi (1,205.09 km) |
| Nicholasville to Estelle (Louisiana) | 639.90 mi (1,029.82 km) |
| Nicholasville to Estero (Florida) | 808.32 mi (1,300.86 km) |
| Nicholasville to Euclid (Ohio) | 302.55 mi (486.91 km) |
| Nicholasville to Eufaula (Alabama) | 414.52 mi (667.11 km) |
