| Nicholasville to Elyria (Ohio) | 274.08 mi (441.10 km) |
| Nicholasville to Emeryville (California) | 2,043.50 mi (3,288.69 km) |
| Nicholasville to Emmaus (Pennsylvania) | 518.43 mi (834.34 km) |
| Nicholasville to Emporia (Kansas) | 632.32 mi (1,017.61 km) |
| Nicholasville to Encinitas (California) | 1,860.09 mi (2,993.53 km) |
| Nicholasville to Endicott (New York) | 535.39 mi (861.63 km) |
| Nicholasville to Endwell (New York) | 537.96 mi (865.77 km) |
| Nicholasville to Englewood (Colorado) | 1,104.69 mi (1,777.83 km) |
| Nicholasville to Englewood (Florida) | 765.32 mi (1,231.67 km) |
| Nicholasville to Englewood (New Jersey) | 601.97 mi (968.78 km) |
| Nicholasville to Englewood (Ohio) | 137.08 mi (220.61 km) |
| Nicholasville to Enid (Oklahoma) | 739.13 mi (1,189.52 km) |
| Nicholasville to Ennis (Texas) | 782.08 mi (1,258.64 km) |
| Nicholasville to Ensley (Florida) | 531.76 mi (855.78 km) |
| Nicholasville to Enterprise (Alabama) | 459.25 mi (739.09 km) |
