| Newcastle under Lyme to Soham | 117.15 mi (188.54 km) |
| Newcastle under Lyme to Solihull | 45.40 mi (73.06 km) |
| Newcastle under Lyme to Sompting | 170.79 mi (274.86 km) |
| Newcastle under Lyme to South Hayling | 162.60 mi (261.68 km) |
| Newcastle under Lyme to South Normanton | 37.34 mi (60.09 km) |
| Newcastle under Lyme to South Ockendon | 148.26 mi (238.60 km) |
| Newcastle under Lyme to South Shields | 140.86 mi (226.70 km) |
| Newcastle under Lyme to Southall | 129.78 mi (208.85 km) |
| Newcastle under Lyme to Southampton | 149.84 mi (241.14 km) |
| Newcastle under Lyme to Southborough | 166.00 mi (267.14 km) |
| Newcastle under Lyme to Southbourne | 159.21 mi (256.22 km) |
| Newcastle under Lyme to Southend | 160.01 mi (257.51 km) |
| Newcastle under Lyme to Southgate | 130.21 mi (209.55 km) |
| Newcastle under Lyme to Southport | 54.44 mi (87.62 km) |
| Newcastle under Lyme to Southwater | 158.76 mi (255.49 km) |
