| New Port Richey East to Superior (Colorado) | 1,510.76 mi (2,431.34 km) |
| New Port Richey East to Superior (Wisconsin) | 1,371.36 mi (2,206.99 km) |
| New Port Richey East to Surprise (Arizona) | 1,795.73 mi (2,889.95 km) |
| New Port Richey East to Susanville (California) | 2,299.52 mi (3,700.71 km) |
| New Port Richey East to Sussex (Wisconsin) | 1,072.86 mi (1,726.60 km) |
| New Port Richey East to Suwanee (Georgia) | 408.24 mi (657.00 km) |
| New Port Richey East to Swansea (Illinois) | 825.38 mi (1,328.33 km) |
| New Port Richey East to Sweetwater (Florida) | 223.03 mi (358.94 km) |
| New Port Richey East to Sweetwater (Texas) | 1,093.94 mi (1,760.53 km) |
| New Port Richey East to Sycamore (Illinois) | 1,006.85 mi (1,620.38 km) |
| New Port Richey East to Sylacauga (Alabama) | 400.35 mi (644.30 km) |
| New Port Richey East to Sylvania (Ohio) | 931.03 mi (1,498.35 km) |
| New Port Richey East to Syosset (New York) | 1,011.60 mi (1,628.01 km) |
| New Port Richey East to Syracuse (New York) | 1,084.49 mi (1,745.32 km) |
| New Port Richey East to Syracuse (Utah) | 1,877.02 mi (3,020.76 km) |
